Description
High Quality 98% Raw Tesofensine Powder
Tesofensine is a potent monoamine reuptake inhibitor research compound that exhibits high-affinity inhibition of the dopamine (DAT), norepinephrine (NET), and serotonin (SERT) transporters. In vitro studies demonstrate strong transporter binding and inhibition activity, with reported IC₅₀ values of approximately 6.8 nM for DAT, 1.7 nM for NET, and 11 nM for SERT, resulting in enhanced monoaminergic signaling. In vivo, tesofensine has shown significant effects on energy balance, appetite regulation, and body weight control in animal models. In rodent studies, tesofensine administration increased extracellular dopamine and norepinephrine levels, reduced food intake, and produced dose-dependent weight loss. Clinical studies in overweight and obese subjects reported substantial weight reduction, with placebo-adjusted weight loss of approximately 4–6% after 24 weeks of treatment. Buy Tesofensine Powder
Tesofensine is widely studied for obesity research, metabolic regulation, appetite suppression, and neuropharmacology applications.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 529217
Name: Tesofensine free base
CAS#: 195875-84-4 (free base)
Chemical Formula: C17H23Cl2NO
Exact Mass: 327.1157
Molecular Weight: 328.27
Elemental Analysis: C, 62.20; H, 7.06; Cl, 21.60; N, 4.27; O, 4.87
195875-84-4 (free base) Tesofensine Tartrate 861205-83-6 (citrate)
Synonym
NS-2330; NS2330; NS 2330; Tesofensine;
IUPAC/Chemical Name
(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane
InChi Key
VCVWXKKWDOJNIT-ZOMKSWQUSA-N
InChi Code
InChI=1S/C17H23Cl2NO/c1-3-21-10-14-13(9-12-5-7-17(14)20(12)2)11-4-6-15(18)16(19)8-11/h4,6,8,12-14,17H,3,5,7,9-10H2,1-2H3/t12-,13+,14+,17+/m0/s1
SMILES Code
CN1[C@@]2([H])[C@H](COCC)[C@@H](C3=CC=C(Cl)C(Cl)=C3)C[C@]1([H])CC2
Appearance
Off-White to Light Yellow Sticky Solid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 – 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Tesofensine is a centrally acting monoamine reuptake inhibitor that exerts its biological effects primarily through inhibition of the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). By blocking the reuptake of these neurotransmitters, tesofensine increases extracellular dopamine, norepinephrine, and serotonin levels in the brain, enhancing monoaminergic signaling pathways involved in appetite control, reward processing, energy expenditure, and metabolic regulation. Preclinical and clinical research suggests that tesofensine may promote appetite suppression, reduce food intake, and support body weight management through modulation of hypothalamic and neural circuits regulating energy homeostasis. Tesofensine has been investigated as a potential therapeutic candidate for obesity, metabolic disorders, and weight management, as well as for neuroscience research exploring monoamine signaling, dopamine-related pathways, and neuropsychiatric mechanisms. For research use only, tesofensine serves as a valuable tool compound for studying neurotransmitter regulation and metabolic physiology. Buy Tesofensine Powder
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